BST2 Antikörper (Internal Region)

Produktnummer ABIN615955

Dieser Ziege Polyklonal Antikörper detektiert spezifisch BST2 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BST2 Antikörper (Internal Region) (ABIN615955)

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser BST2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-BST2 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-ELTEAQKGFQ D

Spezifität: Recognizes CD317 / BST2

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence, from the internal region of the protein sequence according to NP_004326.1. Genename: BST2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Andere Bezeichnung: CD317 / BST2

Hintergrund: Bone marrow stromal Antigen-2 (BST-2) is a 30- to 36- kDa type II transmembrane protein, consisting of 180 amino acids. It has been shown to form a complex with Rho-GTPase activating protein, RICH2 (1). This complex is essential for the organization of subapical actin cytoskeleton. BST-2 protein is expressed on certain bonemarrow stromal cell lines and on various normal tissues. The expression pattern of BST2 is relatively different form another bone marrow stromal antigen 1 (BST1). The BST-2 gene is located on chromosome 19p13.2. BST-2 surface expression on fibroblast cell lines facilitated the stromal cell-dependent growth of a murine bone marrow-derived pre-B-cell line, DW34. Some studies suggest that BST-2 may be involved in pre-B-cell growth development by regulating their surface molecules and cytokines (2). BST2 is also expressed in synovial cell lines from where the BST2 gene was cloned. BST2 is predominantly expressed in liver, lungs, heart, placenta and lower levels in pancreas, kidney, skeletal muscle and brain. Naturally all human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles. This antiviral activity is antagonized by the HIV-1 accessory protein, Vpu. The antiviral activity can be constitutively induced and expressed by interferon-alfa and is consist of protein based Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

Gen-ID: 684

NCBI Accession: NP_004326

UniProt: Q10589

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response