Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1,0 mg/mL
Buffer
PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM sodium chloride, 0.02 % sodium azide as preservative and 50 % glycerol as stabilizer
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Target
FPR1
(Formyl Peptide Receptor 1 (FPR1))
Andere Bezeichnung
fMLP Receptor
Hintergrund
Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection.Synonyms: FPR1, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor, fMet-Leu-Phe receptor