PDIA4 Antikörper (AA 623-638)

Produktnummer ABIN615311

Der Kaninchen Polyklonal anti-PDIA4 Antikörper wird verwendet zum Nachweis von PDIA4 in Proben von Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für PDIA4 Antikörper (AA 623-638) (ABIN615311)

Target: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDIA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PDIA4 Antikörper

Bindungsspezifität: AA 623-638

Spezifität: This antibody reacts to Protein Disulfide Isomerase Family A, Member 4 (PDIA4).

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine, Guinea pig, Hamster, Human, Monkey, Rabbit, Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Protein A Chromatography

Immunogen: PDIA4 antibody was raised against a synthetic peptide based on the sequence of mouse ERp72 (residues 623-638) with a cysteine residue added and coupled to KLH.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % azide and 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu PDIA4

Target: PDIA4 (Protein Disulfide Isomerase Family A, Member 4 (PDIA4))

Andere Bezeichnung: PDIA4

Hintergrund: Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family1 that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.Synonyms: ER marker, ER protein 70, ER protein 72, ERP70, ERP72, ERp-70, ERp-72, Endoplasmic reticulum resident protein 70, Endoplasmic reticulum resident protein 72, Protein Disulfide Isomerase, Protein disulfide-isomerase A4

Gen-ID: 9601

NCBI Accession: NP_004902

UniProt: P13667

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis