USP13 Antikörper (AA 90-200)
Kurzübersicht für USP13 Antikörper (AA 90-200) (ABIN6149996)
Target
Alle USP13 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 90-200
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Sequenz
- MHLKRHVREK VRGASGGALP KRRNSKIFLD LDTDDDLNSD DYEYEDEAKL VIFPDHYEIA LPNIEELPAL VTIACDAVLS SKSPYRKQDP DTWENELPVS KYANNLTQLD N
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 90-200 of human USP13 (NP_003931.2).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:1000 - 1:2000,IHC,1:50 - 1:200
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Kommentare
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HIGH QUALITY
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))
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Andere Bezeichnung
- USP13
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Hintergrund
- Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD. Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data.,USP13,ISOT3,IsoT-3,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP13
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Molekulargewicht
- 90 kDa/97 kDa
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Gen-ID
- 8975
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UniProt
- Q92995
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Pathways
- SARS-CoV-2 Protein Interaktom
Target
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