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USP13 Antikörper (AA 90-200)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch USP13 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6149996

Kurzübersicht für USP13 Antikörper (AA 90-200) (ABIN6149996)

Target

Alle USP13 Antikörper anzeigen
USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))

Reaktivität

  • 53
  • 33
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 52
  • 4
Kaninchen

Klonalität

  • 43
  • 13
Polyklonal

Konjugat

  • 32
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser USP13 Antikörper ist unkonjugiert

Applikation

  • 41
  • 24
  • 20
  • 8
  • 6
  • 5
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 7
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 90-200

    Sequenz

    MHLKRHVREK VRGASGGALP KRRNSKIFLD LDTDDDLNSD DYEYEDEAKL VIFPDHYEIA LPNIEELPAL VTIACDAVLS SKSPYRKQDP DTWENELPVS KYANNLTQLD N

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 90-200 of human USP13 (NP_003931.2).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:1000 - 1:2000,IHC,1:50 - 1:200

    Kommentare

    HIGH QUALITY

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))

    Andere Bezeichnung

    USP13

    Hintergrund

    Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD. Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data.,USP13,ISOT3,IsoT-3,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP13

    Molekulargewicht

    90 kDa/97 kDa

    Gen-ID

    8975

    UniProt

    Q92995

    Pathways

    SARS-CoV-2 Protein Interaktom
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