NEFH Antikörper
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- Target Alle NEFH Antikörper anzeigen
- NEFH (Neurofilament, Heavy Polypeptide (NEFH))
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Reaktivität
- Human, Ratte, Schwein
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NEFH Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), ELISA (Capture)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Porcine, Rat.
- Aufreinigung
- Precipitation methods and size-exclusion chromatography
- Reinheit
- > 95 % pure by SDS-PAGE
- Immunogen
- Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
- Klon
- NF-05
- Isotyp
- IgG1
- Top Product
- Discover our top product NEFH Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS, pH ~7.4, 15 mM Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- DO NOT FREEZE.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8 °C.
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- Target
- NEFH (Neurofilament, Heavy Polypeptide (NEFH))
- Andere Bezeichnung
- Neurofilament H (200 kD) (NEFH Produkte)
- Synonyme
- NF-H antikoerper, NF200 antikoerper, Nfh antikoerper, mKIAA0845 antikoerper, NFH antikoerper, NEFH antikoerper, neurofilament heavy polypeptide antikoerper, neurofilament, heavy polypeptide antikoerper, neurofilament heavy antikoerper, MCYG_06231 antikoerper, Nefh antikoerper, NEFH antikoerper
- Hintergrund
- Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H rod is uniquely long (more than 600 amino acids) compared to other IF proteins and is highly charged (> 24 % Glu, > 25 % Lys), rich in proline (> 12 %) and improverished in cysteine, methionine and aromatic amino acids. Its most remarkable feature is a repetitive sequence that covers more than half its lenght and includes the sekvence motif Lys-Ser-Pro (KSP) greater than 40 times. Plasma neurofilament heavy chain level has been proposed as a marker of axonal injury and clinical use of its degeneration and loss has been suggested as a biomarker of several neurodegenerative diseases.Synonyms: (Neuronal Marker), 200 kDa neurofilament protein, KIAA0845, NEFH, NF-H, NFH, Neurofilament triplet H protein, heavy polypeptide
- Gen-ID
- 9823
- UniProt
- P12037
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