CD4 Antikörper (PE)

Produktnummer ABIN614796

Dieses Anti-CD4-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CD4 in FACS. Geeignet für Maus.

Kurzübersicht für CD4 Antikörper (PE) (ABIN614796)

Target: CD4

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD4 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: GK1-5

Produktdetails anti-CD4 Antikörper (PE)

Spezifität: This antibody reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Immunogen: Mouse CTL clone V4 cells

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, approx. pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE! This product is photosensitive and should be protected from light.

Lagerung: 4 °C

Details zu CD4

Target: CD4

Andere Bezeichnung: CD4

Hintergrund: CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4

Gen-ID: 12504, 10090

UniProt: P06332

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events