PSME3 Antikörper (C-Term)

Produktnummer ABIN6146357

Dieses Anti-PSME3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PSME3 in WB, IHC und IF. Geeignet für Human.

Kurzübersicht für PSME3 Antikörper (C-Term) (ABIN6146357)

Target: PSME3

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PSME3 Antikörper

Bindungsspezifität: C-Term

Sequenz: KVFVMPNGML KSNQQLVDII EKVKPEIRLL IEKCNTVKMW VQLLIPRIED GNNFGVSIQE ETVAELRTVE SEAASYLDQI SRYYITRAKL VSKIAKYPHV EDYRRTVTEI DEKEYISLRL IISELRNQYV TLHDMILKNI EKIKRPRSSN AETLY

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human PSME3 (NP_005780.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PSME3

Target: PSME3

Andere Bezeichnung: PSME3

Hintergrund: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.,PSME3,HEL-S-283,Ki,PA28-gamma,PA28G,PA28gamma,REG-GAMMA,Cancer,Tumor suppressors,p53 pathway,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Ubiquitin,Immunology & Inflammation,PSME3

Molekulargewicht: 29 kDa/30 kDa

Gen-ID: 10197

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA