PRDM6 Antikörper (AA 376-595)

Produktnummer ABIN6146147

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRDM6 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PRDM6 Antikörper (AA 376-595) (ABIN6146147)

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRDM6 Antikörper

Bindungsspezifität: AA 376-595

Sequenz: LQCIAQDENL NVPSTVMEAM CRQDALQPFN KSSKLAPTTQ QRSVVFPQTP CSRNFSLLDK SGPIESGFNQ INVKNQRVLA SPTSTSQLHS EFSDWHLWKC GQCFKTFTQR ILLQMHVCTQ NPDRPYQCGH CSQSFSQPSE LRNHVVTHSS DRPFKCGYCG RAFAGATTLN NHIRTHTGEK PFKCERCERS FTQATQLSRH QRMPNECKPI TESPESIEVD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-595 of human PRDM6 (NP_001129711.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Andere Bezeichnung: PRDM6

Hintergrund: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.,PRDM6,KMT8C,PDA3,PRISM,Epigenetics & Nuclear Signaling,PRDM6

Molekulargewicht: 14 kDa/46 kDa/64 kDa

Gen-ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation