PPARD Antikörper (AA 102-361)

Produktnummer ABIN6146002

Dieses Anti-PPARD-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PPARD in WB und IHC. Geeignet für Human.

Kurzübersicht für PPARD Antikörper (AA 102-361) (ABIN6146002)

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PPARD Antikörper

Bindungsspezifität: AA 102-361

Sequenz: IRMKLEYEKC ERSCKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ANEGSQYNPQ VADLKAFSKH IYNAYLKNFN MTKKKARSIL TGKASHTAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYKEI SVHVFYRCQC TTVETVRELT EFAKSIPSFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD GLLVANGSGF VTREFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGGE

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_803184.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Andere Bezeichnung: PPARD

Hintergrund: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.,PPARD,FAAR,NR1C2,NUC1,NUCI,NUCII,PPARB,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Endocrine and metabolic diseases,Obesity,Cardiovascular,Heart,Cardiac metabolism,PPARD

Molekulargewicht: 38 kDa/40 kDa/45 kDa/49 kDa

Gen-ID: 5467

UniProt: Q03181

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation