PICALM Antikörper (AA 290-460)

Produktnummer ABIN6145606

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PICALM in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PICALM Antikörper (AA 290-460) (ABIN6145606)

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PICALM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PICALM Antikörper

Bindungsspezifität: AA 290-460

Sequenz: IKDSTAASRA TTLSNAVSSL ASTGLSLTKV DEREKQAALE EEQARLKALK EQRLKELAKK PHTSLTTAAS PVSTSAGGIM TAPAIDIFST PSSSNSTSKL PNDLLDLQQP TFHPSVHPMS TASQVASTWG GFTPSPVAQP HPSAGLNVDF ESVFGNKSTN VIVDSGGFDE L

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-460 of human PICALM (NP_001008660.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PICALM

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Andere Bezeichnung: PICALM

Hintergrund: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PICALM,CALM,CLTH,LAP,Signal Transduction,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,PICALM

Molekulargewicht: 59 kDa/66 kDa/68 kDa/70 kDa

Gen-ID: 8301

UniProt: Q13492

Pathways: Synaptic Membrane