PHF19 Antikörper (AA 1-207)

Produktnummer ABIN6145539

Dieses Anti-PHF19-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PHF19 in WB und IF. Geeignet für Human.

Kurzübersicht für PHF19 Antikörper (AA 1-207) (ABIN6145539)

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHF19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PHF19 Antikörper

Bindungsspezifität: AA 1-207

Sequenz: MENRALDPGT RDSYGATSHL PNKGALAKVK NNFKDLMSKL TEGQYVLCRW TDGLYYLGKI KRVSSSKQSC LVTFEDNSKY WVLWKDIQHA GVPGEEPKCN ICLGKTSGPL NEILICGKCG LGYHQQCHIP IAGSADQPLL TPWFCRRCIF ALAVRVSLPS SPVPASPASS SGADQRLPSQ SLSSKQKGHT WALETDSASA TVLGQDL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human PHF19 (NP_001009936.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:100

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PHF19

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Andere Bezeichnung: PHF19

Hintergrund: Polycomb group (PcG protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.,PHF19,MTF2L1,PCL3,TDRD19B,Epigenetics & Nuclear Signaling,Transcription Factors,PHF19

Molekulargewicht: 14 kDa/22 kDa/65 kDa

Gen-ID: 26147

UniProt: Q5T6S3

Pathways: Stem Cell Maintenance