PDP Antikörper (AA 278-537)

Produktnummer ABIN6145404

Der Kaninchen Polyklonal Anti-PDP-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, PDP in Proben von Human zu detektieren.

Kurzübersicht für PDP Antikörper (AA 278-537) (ABIN6145404)

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PDP Antikörper

Bindungsspezifität: AA 278-537

Sequenz: HVDGVDLHVA NTGDSRAMLG VQEEDGSWSA VTLSNDHNAQ NERELERLKL EHPKSEAKSV VKQDRLLGLL MPFRAFGDVK FKWSIDLQKR VIESGPDQLN DNEYTKFIPP NYHTPPYLTA EPEVTYHRLR PQDKFLVLAT DGLWETMHRQ DVVRIVGEYL TGMHHQQPIA VGGYKVTLGQ MHGLLTERRT KMSSVFEDQN AATHLIRHAV GNNEFGTVDH ERLSKMLSLP EELARMYRDD ITIIVVQFNS HVVGAYQNQE

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 278-537 of human PDP1 (NP_060914.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Andere Bezeichnung: PDP1

Hintergrund: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,PDP1,PDH,PDP,PDPC,PPM2A,PPM2C,PDP1

Molekulargewicht: 61 kDa/63 kDa

Gen-ID: 54704

UniProt: Q9P0J1