GDF15 Antikörper (AA 40-243)

Produktnummer ABIN6145370

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GDF15 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GDF15 Antikörper (AA 40-243) (ABIN6145370)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDF15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GDF15 Antikörper

Bindungsspezifität: AA 40-243

Sequenz: EGPALRRSYW RHLRRLVLGP PEPPFSHVCQ VGDPVLRGVA APVERAQLGG PELQRLTQRL VQVMRRRRCV GLSAPQLGVP RQVLALELPE ALCRECPPRQ RALRQMEPFP LRVFVNPSLR VLDSRLVTFP EGCESVAGFL ACVPRFQAVQ ISGLDPNGEQ VVWQASGWAA RIIQHEMDHL QGCLFIDKMD SRTFTNVYWM KVND

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-243 of human PDF (NP_071736.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Andere Bezeichnung: PDF

Hintergrund: Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.,PDF,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Mitochondrial translation,Amino acid metabolism,Nucleotide metabolism,PDF

Molekulargewicht: 27 kDa

Gen-ID: 64146

UniProt: Q9HBH1

Pathways: SARS-CoV-2 Protein Interaktom