alpha KGDHC Antikörper (AA 148-427)

Produktnummer ABIN6145003

Dieses Anti-alpha KGDHC-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von alpha KGDHC in WB, IHC und IF. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für alpha KGDHC Antikörper (AA 148-427) (ABIN6145003)

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha KGDHC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-alpha KGDHC Antikörper

Bindungsspezifität: AA 148-427

Sequenz: DPLGILDADL DSSVPADIIS STDKLGFYGL DESDLDKVFH LPTTTFIGGQ ESALPLREII RRLEMAYCQH IGVEFMFIND LEQCQWIRQK FETPGIMQFT NEEKRTLLAR LVRSTRFEEF LQRKWSSEKR FGLEGCEVLI PALKTIIDKS SENGVDYVIM GMPHRGRLNV LANVIRKELE QIFCQFDSKL EAADEGSGDV KYHLGMYHRR INRVTDRNIT LSLVANPSHL EAADPVVMGK TKAEQFYCGD TEGKKVRPRE RRARQIVKAP CSSMEFRSPT

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human OGDH (NP_001003941.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:10 - 1:100

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-alpha KGDHC Antikörper (ABIN6145003)

Stein, Jadiya, Zhang, McLendon, Abouassaly, Witmer, Anderson, Elrod, Boudreau: "Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency." in: Cell reports, Vol. 23, Issue 13, pp. 3710-3720.e8, (2018) (PubMed).

Details zu alpha KGDHC

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Andere Bezeichnung: OGDH

Hintergrund: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,OGDH,AKGDH,E1k,OGDC,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Lipid Metabolism,Hydrolysis,Cardiovascular,Lipids,OGDH

Molekulargewicht: 48 kDa/115 kDa

Gen-ID: 4967

UniProt: Q02218