NOTCH2 Antikörper (AA 2242-2471)

Produktnummer ABIN6144736

Der Kaninchen Polyklonal Anti-NOTCH2-Antikörper wurde für WB und IF validiert. Er ist geeignet, NOTCH2 in Proben von Human zu detektieren.

Kurzübersicht für NOTCH2 Antikörper (AA 2242-2471) (ABIN6144736)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-NOTCH2 Antikörper

Bindungsspezifität: AA 2242-2471

Sequenz: SRLHPVPVPA DWMNRMEVNE TQYNEMFGMV LAPAEGTHPG IAPQSRPPEG KHITTPREPL PPIVTFQLIP KGSIAQPAGA PQPQSTCPPA VAGPLPTMYQ IPEMARLPSV AFPTAMMPQQ DGQVAQTILP AYHPFPASVG KYPTPPSQHS YASSNAAERT PSHSGHLQGE HPYLTPSPES PDQWSSSSPH SASDWSDVTT SPTPGGAGGG QRGPGTHMSE PPHNNMQVYA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2242-2471 of human NOTCH2 (NP_077719.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Andere Bezeichnung: NOTCH2

Hintergrund: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.,NOTCH2,AGS2,HJCYS,hN2,notch 2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Stem Cells,NOTCH2

Molekulargewicht: 265 kDa

Gen-ID: 4853

UniProt: Q04721

Pathways: Notch Signalweg, Stem Cell Maintenance