MCFD2 Antikörper (AA 27-146)

Produktnummer ABIN6143636

Dieses Anti-MCFD2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MCFD2 in WB und IHC. Geeignet für Human.

Kurzübersicht für MCFD2 Antikörper (AA 27-146) (ABIN6143636)

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCFD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MCFD2 Antikörper

Bindungsspezifität: AA 27-146

Sequenz: EEPAASFSQP GSMGLDKNTV HDQEHIMEHL EGVINKPEAE MSPQELQLHY FKMHDYDGNN LLDGLELSTA ITHVHKEEGS EQAPLMSEDE LINIIDGVLR DDDKNNDGYI DYAEFAKSLQ

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-146 of human MCFD2 (NP_644808.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MCFD2

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Andere Bezeichnung: MCFD2

Hintergrund: This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1, also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D), a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,MCFD2,F5F8D,F5F8D2,LMAN1IP,SDNSF,Signal Transduction,MCFD2

Molekulargewicht: 10 kDa/14 kDa/16 kDa

Gen-ID: 90411

UniProt: Q8NI22