HSPA6 Antikörper (AA 474-643)

Produktnummer ABIN6142046

Produktdetails anti-HSPA6 Antikörper

Target: HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6))

Bindungsspezifität: AA 474-643

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PQIEVTFDID ANGILSVTAT DRSTGKANKI TITNDKGRLS KEEVERMVHE AEQYKAEDEA QRDRVAAKNS LEAHVFHVKG SLQEESLRDK IPEEDRRKMQ DKCREVLAWL EHNQLAEKEE YEHQKRELEQ ICRPIFSRLY GGPGVPGGSS CGTQARQGDP STGPIIEEVD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 474-643 of human HSPA6 (NP_002146.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HSPA6

Target: HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6))

Andere Bezeichnung: HSPA6 (HSPA6 Produkte)

Synonyme: HSPA6 antikoerper, HSP70B' antikoerper, heat shock protein family A (Hsp70) member 6 antikoerper, HSPA6 antikoerper

Hintergrund: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.,HSPA6,HSP70B,Cancer,Tumor biomarkers,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,HSPA6

Molekulargewicht: 71 kDa

Gen-ID: 3310

UniProt: P17066