HSPA2 Antikörper (AA 400-639)

Produktnummer ABIN6142040

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HSPA2 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HSPA2 Antikörper (AA 400-639) (ABIN6142040)

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-HSPA2 Antikörper

Bindungsspezifität: AA 400-639

Sequenz: TPLSLGIETA GGVMTPLIKR NTTIPTKQTQ TFTTYSDNQS SVLVQVYEGE RAMTKDNNLL GKFDLTGIPP APRGVPQIEV TFDIDANGIL NVTAADKSTG KENKITITND KGRLSKDDID RMVQEAERYK SEDEANRDRV AAKNALESYT YNIKQTVEDE KLRGKISEQD KNKILDKCQE VINWLDRNQM AEKDEYEHKQ KELERVCNPI ISKLYQGGPG GGSGGGGSGA SGGPTIEEVD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-639 of human HSPA2 (NP_068814.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HSPA2

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Andere Bezeichnung: HSPA2

Hintergrund: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity.,HSPA2,HSP70-2,HSP70-3,Cancer,Tumor biomarkers,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,HSPA2

Molekulargewicht: 70 kDa

Gen-ID: 3306

UniProt: P54652