GP1BB Antikörper (AA 27-147)

Produktnummer ABIN6141287

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GP1BB in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GP1BB Antikörper (AA 27-147) (ABIN6141287)

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GP1BB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GP1BB Antikörper

Bindungsspezifität: AA 27-147

Sequenz: PAPCSCAGTL VDCGRRGLTW ASLPTAFPVD TTELVLTGNN LTALPPGLLD ALPALRTAHL GANPWRCDCR LVPLRAWLAG RPERAPYRDL RCVAPPALRG RLLPYLAEDE LRAACAPGPL C

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-147 of human GP1BB (NP_000398.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GP1BB

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Andere Bezeichnung: GP1BB

Hintergrund: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.,GP1BB,BDPLT1,BS,CD42C,GPIBB,GPIbbeta,Immunology & Inflammation,CD markers,GP1BB

Molekulargewicht: 21 kDa/43 kDa

Gen-ID: 2812

UniProt: P13224