GNE Antikörper (AA 1-150)

Produktnummer ABIN6141232

Dieses Anti-GNE-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GNE in WB und IHC. Geeignet für Human.

Kurzübersicht für GNE Antikörper (AA 1-150) (ABIN6141232)

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GNE Antikörper

Bindungsspezifität: AA 1-150

Sequenz: METYGYLQRE SCFQGPHELY FKNLSKRNKQ IMEKNGNNRK LRVCVATCNR ADYSKLAPIM FGIKTEPEFF ELDVVVLGSH LIDDYGNTYR MIEQDDFDIN TRLHTIVRGE DEAAMVESVG LALVKLPDVL NRLKPDIMIV HGDRFDALAL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GNE

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Andere Bezeichnung: GNE

Hintergrund: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.,GNE,DMRV,GLCNE,IBM2,NM,Uae1,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cardiovascular,Blood,GNE

Molekulargewicht: 66 kDa/71 kDa/78 kDa/79 kDa/83 kDa

Gen-ID: 10020

UniProt: Q9Y223