FERMT2 Antikörper (AA 380-550)

Produktnummer ABIN6140582

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FERMT2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FERMT2 Antikörper (AA 380-550) (ABIN6140582)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FERMT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-FERMT2 Antikörper

Bindungsspezifität: AA 380-550

Sequenz: KVFKPKKLTL KGYKQYWCTF KDTSISCYKS KEESSGTPAH QMNLRGCEVT PDVNISGQKF NIKLLIPVAE GMNEIWLRCD NEKQYAHWMA ACRLASKGKT MADSSYNLEV QNILSFLKMQ HLNPDPQLIP EQITTDITPE CLVSPRYLKK YKNKQITARI LEAHQNVAQM S

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Andere Bezeichnung: FERMT2

Hintergrund: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.,FERMT2,KIND2,MIG2,PLEKHC1,UNC112,UNC112B,mig-2,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Stem Cells,Mesenchymal Stem Cells,FERMT2

Molekulargewicht: 72 kDa/77 kDa/78 kDa

Gen-ID: 10979

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization