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F13A1 Antikörper (AA 600-732)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch F13A1 in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6140402

Kurzübersicht für F13A1 Antikörper (AA 600-732) (ABIN6140402)

Target

Alle F13A1 Antikörper anzeigen
F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Reaktivität

  • 83
  • 9
  • 9
  • 3
  • 3
Human

Wirt

  • 52
  • 34
  • 3
  • 1
Kaninchen

Klonalität

  • 54
  • 36
Polyklonal

Konjugat

  • 59
  • 6
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser F13A1 Antikörper ist unkonjugiert

Applikation

  • 55
  • 46
  • 37
  • 32
  • 23
  • 19
  • 19
  • 14
  • 8
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 22
    • 8
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 600-732

    Sequenz

    LEQASLHFFV TARINETRDV LAKQKSTVLT IPEIIIKVRG TQVVGSDMTV TVEFTNPLKE TLRNVWVHLD GPGVTRPMKK MFREIRPNST VQWEEVCRPW VSGHRKLIAS MSSDSLRHVY GELDVQIQRR PSM

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 600-732 of human F13A1 (NP_000120.2).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

    Andere Bezeichnung

    F13A1

    Hintergrund

    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.,F13A1,F13A,Cardiovascular,Blood,Coagulation,Serum Proteins,F13A1

    Molekulargewicht

    83 kDa

    Gen-ID

    2162

    UniProt

    P00488
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