EXOSC7 Antikörper (AA 1-291)

Produktnummer ABIN6140380

Der Kaninchen Polyklonal Anti-EXOSC7-Antikörper wurde für WB validiert. Er ist geeignet, EXOSC7 in Proben von Human zu detektieren.

Kurzübersicht für EXOSC7 Antikörper (AA 1-291) (ABIN6140380)

Target: EXOSC7 (Exosome Component 7 (EXOSC7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EXOSC7 Antikörper

Bindungsspezifität: AA 1-291

Sequenz: MASVTLSEAE KVYIVHGVQE DLRVDGRGCE DYRCVEVETD VVSNTSGSAR VKLGHTDILV GVKAEMGTPK LEKPNEGYLE FFVDCSASAT PEFEGRGGDD LGTEIANTLY RIFNNKSSVD LKTLCISPRE HCWVLYVDVL LLECGGNLFD AISIAVKAAL FNTRIPRVRV LEDEEGSKDI ELSDDPYDCI RLSVENVPCI VTLCKIGYRH VVDATLQEEA CSLASLLVSV TSKGVVTCMR KVGKGSLDPE SIFEMMETGK RVGKVLHASL QSVVHKEESL GPKRQKVGFL G

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human EXOSC7 (NP_055819.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu EXOSC7

Target: EXOSC7 (Exosome Component 7 (EXOSC7))

Andere Bezeichnung: EXOSC7

Hintergrund: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9 is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.,EXOSC7,EAP1,RRP42,Rrp42p,hRrp42p,p8,Epigenetics & Nuclear Signaling,EXOSC7

Molekulargewicht: 31 kDa

Gen-ID: 23016

UniProt: Q15024