DDIT4 Antikörper (AA 1-232)

Produktnummer ABIN6139466

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DDIT4 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DDIT4 Antikörper (AA 1-232) (ABIN6139466)

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDIT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-DDIT4 Antikörper

Bindungsspezifität: AA 1-232

Sequenz: MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human DDIT4 (NP_061931.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DDIT4

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Andere Bezeichnung: DDIT4

Hintergrund: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1. Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.,DDIT4,Dig2,REDD-1,REDD1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,mTOR Signaling Pathway,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,Neurodegenerative Diseases Markers,Cardiovascular,Hypoxia,Hypoxia-Regulated,DDIT4

Molekulargewicht: 25 kDa

Gen-ID: 54541

UniProt: Q9NX09

Pathways: Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process