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BCR Antikörper (AA 1-300)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BCR in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6137518

Kurzübersicht für BCR Antikörper (AA 1-300) (ABIN6137518)

Target

Alle BCR Antikörper anzeigen
BCR (Breakpoint Cluster Region (BCR))

Reaktivität

  • 98
  • 56
  • 26
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 93
  • 4
  • 4
Kaninchen

Klonalität

  • 96
  • 5
Polyklonal

Konjugat

  • 61
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BCR Antikörper ist unkonjugiert

Applikation

  • 72
  • 38
  • 34
  • 26
  • 26
  • 26
  • 19
  • 15
  • 14
  • 11
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 30
    • 16
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-300

    Sequenz

    MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BCR (NP_004318.3).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:100

    Kommentare

    HIGH QUALITY

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    BCR (Breakpoint Cluster Region (BCR))

    Andere Bezeichnung

    BCR

    Hintergrund

    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.,BCR,ALL,BCR1,CML,D22S11,D22S662,PHL,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,NF-kB Signaling Pathway,BCR

    Molekulargewicht

    137 kDa/142 kDa

    Gen-ID

    613

    UniProt

    P11274

    Pathways

    Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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