Ataxin 1 Antikörper (AA 586-815)

Produktnummer ABIN6137363

Dieses Anti-Ataxin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Ataxin 1 in WB. Geeignet für Human.

Kurzübersicht für Ataxin 1 Antikörper (AA 586-815) (ABIN6137363)

Target: Ataxin 1 (ATXN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Ataxin 1 Antikörper

Bindungsspezifität: AA 586-815

Sequenz: ELKKVEDLKT EDFIQSAEIS NDLKIDSSTV ERIEDSHSPG VAVIQFAVGE HRAQVSVEVL VEYPFFVFGQ GWSSCCPERT SQLFDLPCSK LSVGDVCISL TLKNLKNGSV KKGQPVDPAS VLLKHSKADG LAGSRHRYAE QENGINQGSA QMLSENGELK FPEKMGLPAA PFLTKIEPSK PAATRKRRWS APESRKLEKS EDEPPLTLPK PSLIPQEVKI CIEGRSNVGK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Ataxin 1

Target: Ataxin 1 (ATXN1)

Andere Bezeichnung: ATXN1

Hintergrund: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.,ATXN1,ATX1,D6S504E,SCA1,ataxin-1,Epigenetics & Nuclear Signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Neuroscience,Neurodegenerative Diseases,ATXN1

Molekulargewicht: 86 kDa

Gen-ID: 6310

UniProt: P54253

Pathways: Synaptic Membrane