NEURL Antikörper (Tyr1248)

Produktnummer ABIN5962106

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NEURL in WB, ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für NEURL Antikörper (Tyr1248) (ABIN5962106)

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEURL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-NEURL Antikörper

Bindungsspezifität: Tyr1248

Spezifität: Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,C erb B2/neu protein,CD340,CD340 antigen,Cerb B2/neu protein,CerbB2,Erb b2 receptor tyrosine kinase 2,ERBB2,ERBB2,HER 2,HER 2/NEU,HER2,Herstatin,Human epidermal growth factor receptor 2,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NEU proto oncogene,Neuro/glioblastoma derived oncogene homolog,Neuroblastoma/glioblastoma derived oncogene homolog,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,TKR1,Tyrosine kinase type cell surface receptor HER2,Tyrosine kinase-type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian),V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian)

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human Neu around the non-phosphorylation site of Tyr1248.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NEURL

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Andere Bezeichnung: Neu

Hintergrund: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A, the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Molekulargewicht: 138kDa

Gen-ID: 2064

UniProt: P04626

Pathways: Notch Signalweg, EGFR Signaling Pathway