ICT1 Antikörper (AA 30-206)

Produktnummer ABIN5775998

Dieser Anti-ICT1 Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von ICT1 in WB, ELISA und FACS. Geeignet für Human.

Kurzübersicht für ICT1 Antikörper (AA 30-206) (ABIN5775998)

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: AT1E9

Produktdetails anti-ICT1 Antikörper

Bindungsspezifität: AA 30-206

Verwendungszweck: Human ICT1 antibody

Aufreinigung: Purified

Immunogen: Recombinant human ICT1 (30-206aa) purified from E. coli

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Details zu ICT1

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Andere Bezeichnung: ICT1

Hintergrund: Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.

NCBI Accession: NP_001536