Phosphoglucomutase 1 Antikörper (AA 1-562)

Produktnummer ABIN5775973

Der Maus Monoklonal Anti-Phosphoglucomutase 1-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, Phosphoglucomutase 1 in Proben von Human zu detektieren.

Kurzübersicht für Phosphoglucomutase 1 Antikörper (AA 1-562) (ABIN5775973)

Target: Phosphoglucomutase 1 (PGM1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Phosphoglucomutase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: AT84G2

Produktdetails anti-Phosphoglucomutase 1 Antikörper

Bindungsspezifität: AA 1-562

Immunogen: Recombinant human PGM1 (1-562aa) purified from E. coli

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu Phosphoglucomutase 1

Target: Phosphoglucomutase 1 (PGM1)

Andere Bezeichnung: PGM1

Hintergrund: PGM1 is an evolutionarily conserved enzyme that regulates one of the most important metabolic carbohydrate trafficking points in prokaryotic and eukaryotic organisms, catalyzing the bi-directional interconversion of glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P). In one direction, G-1-P produced from sucrose catabolism is converted to G-6-P, the first intermediate in glycolysis. In the other direction, conversion of G-6-P to G-1-P generates a substrate for synthesis of UDP-glucose, which is required for synthesis of a variety of cellular constituents, including cell wall polymers and glycoproteins. PGM1 has been used extensively as a genetic marker for isozyme polymorphism among humans. PGM is known to be post-translationally modified by cytoplasmic glycosylation that does not seem to regulate its enzymatic activity but rather is implicated in the localization of the protein. Glucose 1, 6 bisphosphate (Glc-1, 6-P2), a powerful regulator of carbohydrate metabolism, has been demonstrated to be a potent activator of PGM. PGM1 is also modified by phosphorylation on Ser108 as part of its catalytic mechanism. This is shown to be performed by Pak1, a previously identified signaling kinase.

NCBI Accession: NP_002624

Pathways: Cellular Glucan Metabolic Process