PGD
Reaktivität: Human
WB
Wirt: Maus
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Lagerung
4 °C,-20 °C,-80 °C
Informationen zur Lagerung
Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
Target
PGD
(Phosphogluconate Dehydrogenase (PGD))
Andere Bezeichnung
6-phosphogluconate Dehydrogenase/PGD
Hintergrund
PGD (Phosphogluconate dehydrogenas), also known as 6PGD, is a 483 amino acid enzyme that is involved in the pentose phosphate shunt. Pentose is required for nucleic acid biosynthesis and the pentose phosphate cycle is a major source of NADPH. PGD deficiency increases the level of erythrocyte pyruvate kinase (PK) activity and reduces glutathione synthetase (GSH), resulting in hemolysis. Defects in PGD are generally asymptomatic and are inherited in an autosomal dominant fashion.