Connexin 31 Antikörper (pSer368)

Produktnummer ABIN576289

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch Connexin 31 in WB. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für Connexin 31 Antikörper (pSer368) (ABIN576289)

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Connexin 31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Connexin 31 Antikörper

Bindungsspezifität: pSer368

Spezifität: Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.

Aufreinigung: Purified

Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 ( pSer368 ).

Type of Immunogen: Synthetic phospho-peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: WB (1:1000)

Usage: Western Blot: LS-C43142 detects a band of approximately 43kD in rat hippocampus cell lysates.

Kommentare:

Target Species of Antibody: Rat

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 10 mM HEPES,  pH 7.5, 0.09 % sodium azide, 0.01 % BSA, 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Connexin 31

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Andere Bezeichnung: GJB3 / CX31 / Connexin 31

Hintergrund: Name/Gene ID: GJB3
Subfamily: Connexin
Family: Ion Channel

Synonyms: GJB3, Connexin 31, Connexin-31, CX31, DFNA2, Erythrokeratodermia variabilis, Gap junction beta-3 protein, DFNA2B, EKV, Gap junction protein beta 3

Gen-ID: 2707

Pathways: Sensory Perception of Sound