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IDE Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IDE in WB, ELISA, IHC (p) und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN5708390

Kurzübersicht für IDE Antikörper (ABIN5708390)

Target

Alle IDE Antikörper anzeigen
IDE (Insulin-Degrading Enzyme (IDE))

Reaktivität

  • 82
  • 37
  • 33
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 70
  • 16
  • 4
Kaninchen

Klonalität

  • 72
  • 18
Polyklonal

Konjugat

  • 48
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IDE Antikörper ist unkonjugiert

Applikation

  • 71
  • 30
  • 27
  • 15
  • 14
  • 13
  • 12
  • 12
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
  • Aufreinigung

    Antigen affinity purified

    Immunogen

    A recombinant human protein corresponding to amino acids F485-K756 was used as the immunogen for the IDE antibody.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal dilution of the IDE antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL, IHC (FFPE): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells, Direct ELISA: 0.1-0.5 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the IDE antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    IDE (Insulin-Degrading Enzyme (IDE))

    Andere Bezeichnung

    IDE / Insulin degrading enzyme

    Hintergrund

    Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    UniProt

    P14735

    Pathways

    SARS-CoV-2 Protein Interaktom
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