MUC1 Antikörper

Produktnummer ABIN5707946

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch MUC1 in IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MUC1 Antikörper (ABIN5707946)

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MCN01-2R

Produktdetails anti-MUC1 Antikörper

Aufreinigung: Purified

Reinheit: Protein A affinity chromatography

Immunogen: Human milk fat globule membranes were used as the immunogen for this recombinant MUC1 antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Titration of the recombinant MUC1 may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant MUC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC1 / Mucin-1

Hintergrund: Mucin-1/MUC1 protein is encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Family members are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. MUC1 is a transmembrane protein normally expressed on the apical borders of secretory epithelial cells. Overexpression is often associated with colon, breast, ovarian, lung and pancreatic cancers. The dominant epitope of this MAb involves both amino acids as well as sugar moieties. Its epitope is destroyed by desialylation i.e. treatment with Neuraminidase.

Gen-ID: 4582

Pathways: Negative Regulation of intrinsic apoptotic Signaling