Filaggrin Antikörper (AA 198-288)

Produktnummer ABIN5707859

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch Filaggrin in IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Filaggrin Antikörper (AA 198-288) (ABIN5707859)

Target: Filaggrin (FLG)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Filaggrin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: FLG-1957R

Produktdetails anti-Filaggrin Antikörper

Bindungsspezifität: AA 198-288

Aufreinigung: Purified

Reinheit: Protein G affinity chromatography

Immunogen: Amino acids 198-288 of human Filaggrin were used as the immunogen for this recombinant FLG antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant FLG antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant FLG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Filaggrin

Target: Filaggrin (FLG)

Andere Bezeichnung: Filaggrin

Hintergrund: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Pathways: Sensory Perception of Sound, Stem Cell Maintenance