Rekombinanter Integrin beta 3 Antikörper

Produktnummer ABIN5707545

Der Kaninchen Monoklonal anti-Integrin beta 3 Antikörper wird verwendet zum Nachweis von Integrin beta 3 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Integrin beta 3 Antikörper (ABIN5707545)

Target: Integrin beta 3 (ITGB3)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: ITGB3-2166R

Produktdetails anti-Integrin beta 3 Antikörper

Verwendungszweck: Recombinant Integrin beta 3 Antibody / ITGB3 / CD61 (azide and preservative free)

Aufreinigung: Protein A affinity

Immunogen: Human recombinant protein was used as the immunogen for the recombinant Integrin beta 3 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Titration of the recombinant Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: Integrin beta 3

Hintergrund: Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alpha-IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex