Integrin beta 3 Antikörper

Produktnummer ABIN5707545

Der Kaninchen Monoklonal Anti-Integrin beta 3-Antikörper wurde für IHC (p) validiert. Er ist geeignet, Integrin beta 3 in Proben von Human zu detektieren.

Kurzübersicht für Integrin beta 3 Antikörper (ABIN5707545)

Target: Integrin beta 3 (ITGB3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: ITGB3-2166R

Produktdetails anti-Integrin beta 3 Antikörper

Aufreinigung: Purified

Reinheit: Protein A affinity

Immunogen: Human recombinant protein was used as the immunogen for the recombinant Integrin beta 3 antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Titration of the recombinant Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: Integrin beta 3 / ITGB3 / CD61

Hintergrund: Reacts with human Integrin beta 3, also called CD61. It associates with the α,V-chain (CD51) to form vitronectin receptor, or with the α,IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex