FOXP3 Antikörper (N-Term) (FITC)

Produktnummer ABIN5707213

Produktdetails anti-FOXP3 Antikörper (FITC)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Bindungsspezifität: N-Term

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Spezifität: Mouse Foxp3 (Mr ~57 kDa). Does not cross react with Human Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other activated T cells also express CD25.1,2 The most convincible molecular marker of Treg cells is Forkhead box protein 3 (Foxp3) which is expressed in the nucleus.3 Anti-Foxp3 antibodies are now widely applied to identify the roles of Treg cells in the development of many diseases, such as cancer, autoimmune disease, and organ transplantation.4,5,6 Scientists found that the over-activation of Treg cells may cause cancer cells to escape from immune surveillance 5. Conversely, patients with autoimmune diseases such as psoriasis, systemic lupus erythematous (SLE) have relative dysfunction of Foxp3 positive cells.7,8 Immunologists are trying to induce immune tolerance in organ transplantation using Treg cells.6

Produktmerkmale: Rat Anti-Mouse Foxp3-FITC

Immunogen: N-terminal recombinant Mouse Foxp3

Klon: SB168a

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: Flow cytometry
• Working Dilutions: Flow Cytometry: FITC conjugate < 1.0 g/106 cells AF647 conjugate < 0.2 g/106 cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.1 mg in 0.2 mL PBS/Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2- 8°C

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: Foxp3 (FOXP3 Produkte)

Synonyme: foxp3 antikoerper, FOXP3 antikoerper, AIID antikoerper, DIETER antikoerper, IPEX antikoerper, PIDX antikoerper, XPID antikoerper, JM2 antikoerper, scurfin antikoerper, sf antikoerper, RGD1562112 antikoerper, forkhead box P3 antikoerper, forkhead box P3a antikoerper, forkhead box P3 L homeolog antikoerper, FOXP3 antikoerper, foxp3a antikoerper, foxp3 antikoerper, foxp3.L antikoerper, Foxp3 antikoerper

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation