DCLRE1B Antikörper

Produktnummer ABIN5703600

Dieses Anti-DCLRE1B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DCLRE1B in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für DCLRE1B Antikörper (ABIN5703600)

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLRE1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-DCLRE1B Antikörper

Immunogen: DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu DCLRE1B

Target: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Andere Bezeichnung: DCLRE1B

Hintergrund: Synonyms:SNM1B Background:5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Molekulargewicht: 60 kDa

Gen-ID: 64858

UniProt: Q9H816