BHLHE41 Antikörper

Produktnummer ABIN5702192

Produktdetails anti-BHLHE41 Antikörper

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BHLHE41 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogen: basic helix-loop-helix family, member e41

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BHLHE41

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Andere Bezeichnung: BHLHE41 (BHLHE41 Produkte)

Synonyme: BHLHB3 antikoerper, dec2 antikoerper, bhlhb3 antikoerper, sharp1 antikoerper, sharp-1 antikoerper, MGC108143 antikoerper, DEC2 antikoerper, SHARP1 antikoerper, hDEC2 antikoerper, 6430520M22Rik antikoerper, Bhlhb2l antikoerper, Bhlhb3 antikoerper, Sharp1 antikoerper, Dec2 antikoerper, SHARP-1 antikoerper, basic helix-loop-helix family member e41 antikoerper, basic helix-loop-helix family, member e41 antikoerper, BHLHE41 antikoerper, bhlhe41 antikoerper, Bhlhe41 antikoerper

Hintergrund: Synonyms:BHLHB3, DEC2, SHARP1 Background:Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Molekulargewicht: 51 kDa,75 kDa

Gen-ID: 79365

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development