RAB7B Antikörper

Produktnummer ABIN5698229

Der Kaninchen Polyklonal Anti-RAB7B Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, RAB7B in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für RAB7B Antikörper (ABIN5698229)

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAB7B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RAB7B Antikörper

Verwendungszweck: RAB7B antibody

Immunogen: RAB7B, member RAS oncogene family

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

human heart tissue were subjected to SDS PAGE followed by western blot with FNab07044(RAB7B antibody) at dilution of 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RAB7B

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Andere Bezeichnung: RAB7B

Hintergrund:

Synonyms: Ras-related protein Rab-7b|RAB7B

Background: Controls vesicular trafficking from endosomes to the trans-Golgi network(TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF-and EGFR degradation pathway.

Gen-ID: 338382

UniProt: Q96AH8