ACTN1 Antikörper (AA 272-490)

Produktnummer ABIN5697056

Der Kaninchen Polyklonal Anti-ACTN1-Antikörper wurde für WB, IHC, ELISA und IF validiert. Er ist geeignet, ACTN1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ACTN1 Antikörper (AA 272-490) (ABIN5697056)

Target: ACTN1 (Actinin, alpha 1 (ACTN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACTN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-ACTN1 Antikörper

Bindungsspezifität: AA 272-490

Verwendungszweck: ACTN1 antibody

Immunogen:

Immunogen sequence: 272-490aa

Immunogen: actinin, alpha 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:1000-1:10000 IHC : 1:50-1:500 IF : 1:50-1:500

Kommentare:

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab00322( a-Actinin Antibody) at dilution of 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu ACTN1

Target: ACTN1 (Actinin, alpha 1 (ACTN1))

Andere Bezeichnung: ACTN1

Hintergrund:

Synonyms: Alpha-actinin-1|Alpha-actinin cytoskeletal isoform|F-actin cross-linking protein|Non-muscle alpha-actinin-1|ACTN1

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 103 kDa

UniProt: P12814

Pathways: Cell-Cell Junction Organization