Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SCRIB Antikörper (AA 172-409)

SCRIB Reaktivität: Human, Maus, Ratte WB, ELISA, IF, FACS, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5693286
  • Target Alle SCRIB Antikörper anzeigen
    SCRIB (Scribbled Homolog (SCRIB))
    Bindungsspezifität
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 172-409
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 12
    • 2
    Kaninchen
    Klonalität
    • 14
    Polyklonal
    Konjugat
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCRIB Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-SCRIBBLE Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-SCRIBBLE Antibody Picoband® (ABIN5693286). Tested in ELISA, Flow Cytometry, IF, IHC-P, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Immunogen
    E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409).
    Isotyp
    IgG
    Top Product
    Discover our top product SCRIB Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL
    Immunocytochemistry/Immunofluorescence, 2 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    ELISA, 0.1-0.5 μg/mL
    1. L E Dow, J S Kauffman, J Caddy, A S Peterson, S M Jane, S M Russell & P O Humbert (April 2007). "The tumour-suppressor Scribble dictates cell polarity during ed epithelial migration: regulation of Rho GTPase recruitment to the leading edge". Oncogene. 26 (16): 2272-82. 2. Yi Qin, Christopher Capaldo, Barry M. Gumbiner & Ian G. Macara (December 2005). "The mammalian SCRIB polarity protein regulates epithelial cell adhesion and migration through E-cadherin". JCB. 171 (6): 1061-71.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    SCRIB (Scribbled Homolog (SCRIB))
    Andere Bezeichnung
    SCRIB (SCRIB Produkte)
    Hintergrund

    Synonyms: Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL

    Tissue Specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

    Background: SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.

    Molekulargewicht
    240 kDa
    Gen-ID
    23513
    UniProt
    Q14160
    Pathways
    Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization
Sie sind hier:
Chat with us!