MDC1 Antikörper (AA 534-626)
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- Target Alle MDC1 Antikörper anzeigen
- MDC1 (Mdc1 (MDC1))
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Bindungsspezifität
- AA 534-626
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MDC1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), ELISA
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
- Rabbit IgG polyclonal antibody for MDC1 detection. Tested with IHC-P, Direct ELISA in Human.
- Immunogen
- E. coli-derived human MDC1 recombinant protein (Position: A534-Q626).
- Top Product
- Discover our top product MDC1 Primärantikörper
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- Applikationshinweise
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Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Application Details: Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
Direct ELISA, 0.1-0.5 μg/mL - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
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- Target
- MDC1 (Mdc1 (MDC1))
- Andere Bezeichnung
- MDC1 (MDC1 Produkte)
- Synonyme
- 6820401C03 antikoerper, AA413496 antikoerper, Nfbd1 antikoerper, mKIAA0170 antikoerper, NFBD1 antikoerper, mediator of DNA damage checkpoint 1 antikoerper, mediator of DNA-damage checkpoint 1 antikoerper, Mdc1 antikoerper, MDC1 antikoerper
- Hintergrund
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Synonyms: Mediator of DNA damage checkpoint protein 1, Nuclear factor with BRCT domains 1, MDC1, KIAA0170, NFBD1
Tissue Specificity: Highly expressed in testis.
Background: Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
- UniProt
- Q14676
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