AGRP Antikörper (AA 82-131)
Kurzübersicht für AGRP Antikörper (AA 82-131) (ABIN5693160)
Target
Alle AGRP Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 82-131
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Verwendungszweck
- Anti-AGRP Antibody
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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Produktmerkmale
- Anti-AGRP Antibody Picoband® (ABIN5693160). Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.
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Immunogen
- E. coli-derived mouse AGRP recombinant protein (Position: S82-T131).
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Isotyp
- IgG
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Applikationshinweise
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (Oct 1997). "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein". Science. 278 (5335): 135-8. 2. Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (Mar 1997). "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice". Genes & Development.11 (5): 593-602. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
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Andere Bezeichnung
- Agrp
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Hintergrund
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Synonyms: Agouti-related protein, Agrp, Agrt, Art
Tissue Specificity: Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
Background: Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
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Molekulargewicht
- 49 kDa
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Gen-ID
- 11604
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UniProt
- P56473
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Pathways
- Feeding Behaviour, Photoperiodism
Target
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