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AGRP Antikörper (AA 82-131)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AGRP in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN5693160

Kurzübersicht für AGRP Antikörper (AA 82-131) (ABIN5693160)

Target

Alle AGRP Antikörper anzeigen
AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))

Reaktivität

Human, Ratte, Maus

Wirt

  • 51
  • 5
  • 3
  • 2
Kaninchen

Klonalität

  • 54
  • 7
Polyklonal

Konjugat

  • 36
  • 13
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AGRP Antikörper ist unkonjugiert

Applikation

  • 37
  • 25
  • 19
  • 13
  • 9
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 10
    • 9
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    AA 82-131

    Verwendungszweck

    Anti-AGRP Antibody

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-AGRP Antibody Picoband® (ABIN5693160). Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

    Immunogen

    E. coli-derived mouse AGRP recombinant protein (Position: S82-T131).

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    ELISA, 0.1-0.5 μg/mL
    1. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (Oct 1997). "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein". Science. 278 (5335): 135-8. 2. Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (Mar 1997). "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice". Genes & Development.11 (5): 593-602.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))

    Andere Bezeichnung

    Agrp

    Hintergrund

    Synonyms: Agouti-related protein, Agrp, Agrt, Art

    Tissue Specificity: Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.

    Background: Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.

    Molekulargewicht

    49 kDa

    Gen-ID

    11604

    UniProt

    P56473

    Pathways

    Feeding Behaviour, Photoperiodism
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