IDE Antikörper (AA 485-756) (DyLight 488)

Produktnummer ABIN7354609

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IDE in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IDE Antikörper (AA 485-756) (DyLight 488) (ABIN7354609)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IDE Antikörper ist konjugiert mit DyLight 488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-IDE Antikörper (DyLight 488)

Bindungsspezifität: AA 485-756

Verwendungszweck: Anti-Human IDE DyLight® 488 conjugated Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Human IDE DyLight® 488 conjugated Antibody -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: E. coli-derived human IDE recombinant protein (Position: F485-K756).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: IDE insulin-degrading enzyme". 2. Affholter JA, Fried VA, Roth RA (Dec 1988). "Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III". Science. 242 (4884): 1415-8.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Details zu IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Andere Bezeichnung: IDE

Hintergrund:

Synonyms: Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE

Background: Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 39 kDa

Gen-ID: 416

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interaktom