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DC-SIGN/CD209 Antikörper

CD209 Reaktivität: Human WB, FACS, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5693101
  • Target Alle DC-SIGN/CD209 (CD209) Antikörper anzeigen
    DC-SIGN/CD209 (CD209) (CD209)
    Reaktivität
    • 89
    • 24
    • 20
    • 1
    Human
    Wirt
    • 60
    • 42
    • 2
    • 1
    Kaninchen
    Klonalität
    • 58
    • 47
    Polyklonal
    Konjugat
    • 51
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DC-SIGN/CD209 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 39
    • 29
    • 27
    • 25
    • 13
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-DC-SIGN/CD209 Antibody Picoband®
    Sequenz
    MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLA
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-DC-SIGN/ Antibody Picoband® (ABIN5693101). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human DC-SIGN.
    Isotyp
    IgG
    Top Product
    Discover our top product CD209 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Flow Cytometry, 1-3 μg/1x106 cells1. Barreiro, L. B., Neyrolles, O., Babb, C. L., Tailleux, L., Quach, H., McElreavey, K., van Helden, P. D., Hoal, E. G., Gicquel, B., Quintana-Murci, L. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med. 3: e20, 2006. 2. Bashirova, A. A., Wu, L., Cheng, J., Martin, T. D., Martin, M. P., Benveniste, R. E., Lifson, J. D., KewalRamani, V. N., Hughes, A., Carrington, M. Novel member of the CD209 (DC-SIGN) gene family in primates. J. Virol. 77: 217-227, 2003.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    DC-SIGN/CD209 (CD209) (CD209)
    Andere Bezeichnung
    CD209 (CD209 Produkte)
    Hintergrund

    Synonyms: CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN, DC-SIGN1, CD209, CD209, CLEC4L

    Tissue Specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

    Background: DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene. DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

    Molekulargewicht
    46 kDa
    Gen-ID
    30835
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