LPAR6 Antikörper

Produktnummer ABIN5693041

Der Kaninchen Polyklonal Anti-LPAR6-Antikörper wurde für WB und FACS validiert. Er ist geeignet, LPAR6 in Proben von Human zu detektieren.

Kurzübersicht für LPAR6 Antikörper (ABIN5693041)

Target: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPAR6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-LPAR6 Antikörper

Verwendungszweck: Anti-P2RY5/LPAR6 Antibody Picoband®

Sequenz: DTIQNSIKMK NWSVRRSDFR FSEVHGAENF IQHNLQTLK

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-P2RY5/LPAR6 Antibody Picoband® (ABIN5693041). Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human P2RY5, which shares 92.3% and 89.7% amino acid (aa) sequence identity with mouse and rat P2RY5, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Nahum, S., Morice-Picard, F., Taieb, A., Sprecher, E. A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp. Clin. Exp. Derm. 36: 188-194, 2010. 2. Shimomura, Y., Wajid, M., Ishii, Y., Shapiro, L., Petukhova, L., Gordon, D., Christiano, A. M.Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nature Genet. 40: 335-339, 2008.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu LPAR6

Target: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Andere Bezeichnung: LPAR6

Hintergrund:

Synonyms: Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor, LPAR6, P2RY5

Tissue Specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.

Background: Lysophosphatidic acid receptor 6 also known as LPA6, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 39 kDa

Gen-ID: 10161

UniProt: P43657