CYBB Antikörper (AA 416-500)
Kurzübersicht für CYBB Antikörper (AA 416-500) (ABIN5692996)
Target
Alle CYBB Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- AA 416-500
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                                            Verwendungszweck
- Anti-NOX2/gp91phox/CYBB Antibody Picoband®
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                                            Kreuzreaktivität (Details)
- No cross-reactivity with other proteins.
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                                            Produktmerkmale
- Anti-NOX2/gp91phox/CYBB Antibody Picoband® (ABIN5692996). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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                                            Immunogen
- E. coli-derived human NOX2/gp91phox recombinant protein (Position: F416-D500).
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                                            Isotyp
- IgG
 
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                                            Applikationshinweise
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                        Western blot, 0.1-0.5 μg/mL
 ELISA, 0.1-0.5 μg/mL
 1. Bionda, C., Li, X. J., van Bruggen, R., Eppink, M., Roos, D., Morel, F., Stasia, M.-J. Functional analysis of two-amino acid substitutions in gp91phox in a patient with X-linked flavocytochrome b(558)-positive chronic granulomatous disease by means of transgenic PLB-985 cells. Hum. Genet. 115: 418-427, 2004. 2. Bolscher, B. G. J. M., de Boer, M., de Klein, A., Weening, R. S., Roos, D. Point mutations in the beta-subunit of cytochrome b(558) leading to X-linked chronic granulomatous disease. Blood 77: 2482-2487, 1991. 3. "Entrez Gene: CYBB cytochrome b-245, beta polypeptide (chronic granulomatous disease)".
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Lyophilized
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                                            Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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                                            Konzentration
- 500 μg/mL
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                                            Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Lagerung
- 4 °C,-20 °C
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                                            Informationen zur Lagerung
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                        Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. 
 It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
 
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                                            : "Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation."    in: Scientific reports, Vol. 6, pp. 30146, (2018)         (PubMed).        
 : "Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity." in: Scientific reports, Vol. 6, pp. 23135, (2017) (PubMed).
 : "Obligatory role for GPER in cardiovascular aging and disease." in: Science signaling, Vol. 9, Issue 452, pp. ra105, (2017) (PubMed).
 : "D?galactose?induced mitochondrial DNA oxidative damage in the auditory cortex of rats." in: Molecular medicine reports, Vol. 10, Issue 6, pp. 2861-7, (2014) (PubMed).
 
 
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                                            : "Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation."    in: Scientific reports, Vol. 6, pp. 30146, (2018)         (PubMed).        
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    - CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
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                                            Andere Bezeichnung
- CYBB
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                                            Hintergrund
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                        Synonyms: Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b (558) subunit beta, Cytochrome b558 subunit beta, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, gp91-phox, p22 phagocyte B-cytochrome, CYBB, NOX2 Tissue Specificity: Detected in neutrophils (at protein level). Background: NOX2 (NADPH OXIDASE 2), also called CYBB (CYTOCHROME b (-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein. NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling). 
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                                            Molekulargewicht
- 65 kDa
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                                            Gen-ID
- 1536
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                                            UniProt
- P04839
 Target
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