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ADAM10 Antikörper (AA 214-325)

Der Kaninchen Polyklonal Anti-ADAM10-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, ADAM10 in Proben von Human, Ratte und Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN5692975

Kurzübersicht für ADAM10 Antikörper (AA 214-325) (ABIN5692975)

Target

Alle ADAM10 Antikörper anzeigen
ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reaktivität

  • 79
  • 33
  • 31
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 67
  • 19
  • 2
  • 1
Kaninchen

Klonalität

  • 59
  • 30
Polyklonal

Konjugat

  • 47
  • 5
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ADAM10 Antikörper ist unkonjugiert

Applikation

  • 56
  • 25
  • 21
  • 19
  • 17
  • 15
  • 13
  • 13
  • 8
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 214-325

    Verwendungszweck

    Anti-ADAM10 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-ADAM10 Antibody Picoband® (ABIN5692975). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Immunogen

    E. coli-derived human ADAM10 recombinant protein (Position: T214-D325).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    ELISA, 0.1-0.5 μg/mL
    1. Lunn, C. A., Fan, X., Dalie, B., Miller, K., Zavodny, P. J., Narula, S. K., Lundell, D.Purification of ADAM 10 from bovine spleen as a TNFalpha convertase.FEBS Lett. 400: 333-335, 1997. 2. Wolfsberg, T. G., Primakoff, P., Myles, D. G., White, J. M.ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.J. Cell Biol. 131: 275-278, 1995. 3. Yamazaki, K., Mizui, Y., Tanaka, I.Radiation hybrid mapping of human ADAM10 gene to chromosome 15.Genomics 45: 457-459, 1997.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Lin, Huang, Xie, Zhou, Yang, Huang: "Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the soluble ULBP2 protein." in: Oncotarget, Vol. 7, Issue 43, pp. 70092-70099, (2018) (PubMed).

  • Target

    ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

    Andere Bezeichnung

    ADAM10

    Hintergrund

    Synonyms: Disintegrin and metalloproteinase domain-containing protein 10, ADAM 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM10, KUZ, MADM

    Tissue Specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.

    Background: ADAM10, A Disintegrin and Metalloproteinase Domain 10, is also known as AD10. ADAM10 is a member of the ADAM family and members of this family are cell surface proteins with a unique structure possessing both potential adhesion and protease function. The ADAM10 gene is mapped to chromosome 15q21.3-q23. ADAM proteins contain an N-terminal signal sequence, followed by a prodomain, a metalloprotease-like domain, a disintegrin-like domain, a cysteine-rich region, an EGF -like repeat, a transmembrane domain, and a C-terminal cytoplasmic tail. Conversion of the membrane-bound precursor to a secreted mature protein is mediated by a protease termed TNFA convertase. ADAM10 possesses TNFA convertase activity.

    Molekulargewicht

    72 kDa

    Gen-ID

    102

    UniProt

    O14672

    Pathways

    Notch Signalweg, EGFR Signaling Pathway
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