Arylsulfatase A Antikörper (C-Term) (DyLight 488)

Produktnummer ABIN5692788

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Arylsulfatase A in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Arylsulfatase A Antikörper (C-Term) (DyLight 488) (ABIN5692788)

Target: Arylsulfatase A (ARSA)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Arylsulfatase A Antikörper ist konjugiert mit DyLight 488

Applikation: Flow Cytometry (FACS)

Klon: 4C10

Produktdetails anti-Arylsulfatase A Antikörper (DyLight 488)

Bindungsspezifität: AA 454-482, C-Term

Verwendungszweck: Anti-Human ARSA DyLight® 488 conjugated Antibody(monoclonal, 4C10)

Sequenz: QALKQLQLLK AQLDAAVTFG PSQVARGED

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Human ARSA DyLight® 488 conjugated Antibody (monoclonal, 4C10) (ABIN5692787)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ARSA, different from the related mouse sequence by six amino acids.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Fujii T, Kobayashi T, Honke K et al. (1992). "Proteolytic processing of human lysosomal arylsulfatase A". Biochim. Biophys. Acta 1122 (1): 93-8. 2. Kondo R, Wakamatsu N, Yoshino H et al. (1991)."Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy". Am. J. Hum. Genet. 48 (5): 971-8. 3. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). "Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy". Hum. Mol. Genet. 14 (9): 1139-52.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Details zu Arylsulfatase A

Target: Arylsulfatase A (ARSA)

Andere Bezeichnung: ARSA

Hintergrund:

Synonyms: Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA

Background: Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Molekulargewicht: 39 kDa

Gen-ID: 410

UniProt: P15289